Rabies is an acute, progressive encephalomyelitis caused by lyssaviruses. This zoonosis occurs worldwide in mammals, with dogs, bats, and wild carnivores as the principal reservoirs. Typical clinical signs include acute behavioral changes and progressive paralysis. The disease is fatal once clinical signs appear; however, appropriate and timely administration of local wound care, immune globulin, and vaccination can prevent disease in unvaccinated humans after exposure. Vaccines are available for domestic animals, wildlife, and humans to prevent rabies and to help control transmission in reservoir populations - Merck Veterinary Manual |
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